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cenobamate will minimize the level or influence of fentanyl transdermal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Closely. Boost dose of CYP3A4 substrate, as necessary, when coadministered with cenobamate.amobarbital will reduce the extent or result of fentanyl transdermal by impacting hepatic/intestinal enzyme